糖尿病患者发生皮肤溃疡,难治的不少,如病势进行性加重,必须进行皮肤移植,切断患部等外科处理,从而成为糖尿病更难控制的原因,而且在保守疗法中,有效疗法较少。十多年来,有报告对皮肤溃疡的胰岛素局部疗法,主要是用胰岛素生理盐水的湿布疗法,而用软膏剂型的报道却很少。本文用Wifepsol为基质制成的最近使用的胰岛素软膏与 Diabetic patients with skin ulcers, refractory many, such as the progressive increase in the disease, the skin must be transplanted, cut off the affected area and other surgical treatment, which became more difficult to control the reasons for diabetes, and conservative treatment, less effective therapy. For more than a decade, topical insulin therapies for skin ulcers have been reported, primarily using damp-cloth therapy with insulin saline, and few reports using ointment formulations. This article uses Wifepsol as a matrix made of recently used insulin ointment and