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报道了CA-242和CA19-9免疫测定对19例胆囊癌和205例良性胆囊疾病的诊断和鉴别诊断的临床价值。显示CA-242和CA19-9的敏感度分别为84.2%和94.7%;特异性为94.6%和72.7%;诊断符合率为93.8%和74.6%,CA-242测定的特异性和符合率均优于CA19-9。本文还探讨了高胆红素血症对CA-242和CA19-9测定的影响,通过对慢性肝病黄疸患者血清的测定和胆囊疾病胆汁和血清联合测定的比较后发现:高胆红素血症对CA19-9测定影响很大,是假阳性的主要原因,但对CA-242测定的影响则很小,因此,判断临床结果时,应高度重视高胆红素血症的影响。
Reported the clinical value of CA-242 and CA19-9 immunoassay in the diagnosis and differential diagnosis of 19 cases of gallbladder cancer and 205 cases of benign gallbladder disease. The sensitivity and specificity of CA-242 and CA19-9 were 84.2% and 94.7%, 94.6% and 72.7% respectively, and the diagnostic coincidence rates were 93.8% and 74.6% At CA19-9. This article also explored the impact of hyperbilirubinemia on the determination of CA-242 and CA19-9, by the determination of serum in patients with chronic liver disease jaundice and gallbladder disease bile and serum combined with the determination of the comparison found that: hyperbilirubinemia CA19-9 determination of a great impact, is the main reason for false positive, but the determination of CA-242 is very small, therefore, to determine the clinical outcome, should pay high attention to the impact of hyperbilirubinemia.