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目的报道1例因多变根毛霉引起的面部感染。方法经真菌镜检、培养和病理诊断为面部多变根毛霉病。结果患者5岁,因摔跤行鼻骨复位术后,面部出现红色丘疹,斑块,肉芽肿,2003年来我院诊断为面部毛霉病。2004年2月根据药敏试验选择酮康唑200 mg／d治疗2个月好转。因其他原因停止治疗,7个月后病情恶化,面部浸润性斑块,坏死,结黑色痂,脓性分泌物,上唇和上腭部分缺失,再次真菌镜检和培养鉴定为多变根毛霉。2004年12月给予两性霉素B治疗2个月,总剂量为50 mg／kg,明显好转,加用伊曲康唑 100 mg／d治疗。结论多变毛霉可引起皮肤组织浸润性感染,两性霉素B治疗有效。
Objective To report a case of facial infection caused by Rhizopus variabilis. Methods After fungal microscopic examination, culture and pathology, it was diagnosed as Rhizoctonia solani. Results 5-year-old patient, due to wrestling nasal bone reduction surgery, the face red papules, plaques, granulomas, 2003 to our hospital diagnosis of facial Mucor. February 2004 Susceptibility test based on the choice of ketoconazole 200 mg / d treatment for 2 months improved. The treatment was stopped for other reasons and the condition deteriorated after 7 months. The facial infiltrative plaques, necrosis, knot black scab, purulent secretions, the upper lip and the palate were partially absent, and fungal microscopic examination and culture were again identified as Rhizopus variabilis. December 2004 amphotericin B treatment for 2 months, the total dose of 50 mg / kg, significantly improved, plus itraconazole 100 mg / d treatment. Conclusion Mucor can cause infiltration of skin tissue infections, amphotericin B treatment is effective.