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本文采用乳胶凝集法ELISA法测定了145例自身免疫病患者（分6组）及34例正常人血清中RF的滴度及IgM、IgA、IgG3种型别。结果显示各疾病组IgM、IgA－RF均高于正常人；IgG－RF除硬皮病、PM／DM外，其他各组亦高于正常人。RA患者3种RF平行增高；SS患者以IgM－RF升高为主。RF滴度对RA的特异性随滴度（1：320以上）增高而增强。曲线拟合分析显示RF滴度能够反应IgM－RF的水平。
In this paper, latex agglutination ELISA method was used to determine the RF titer and IgM, IgA, IgG3 types in serum of 145 patients with autoimmune disease (group 6) and 34 normal persons. The results showed that IgM and IgA-RF in each disease group were higher than those in normal people. In addition to scleroderma and PM / DM, IgG-RF was also higher in all other groups than in normal people. RA patients with three kinds of RF increased in parallel; SS patients with IgM-RF-based. The specificity of RF titer for RA increases with increasing titer (above 1: 320). Curve fitting analysis showed that RF titers responded to IgM-RF levels.