论文部分内容阅读
目的分析急性心肌梗死患者采用血栓抽吸联合替罗非班介入治疗的临床疗效。方法选取2012年6月至2014年6月期间急诊收入院的急性心肌梗死患者共84例为研究对象,随机分成观察、对照两组,每组各42例患者。两组患者均进行经皮冠状动脉介入术(PCI)治疗,观察组同时应用血栓抽吸术联合替罗非班治疗,对照组单独进行替罗非班治疗。对比两组患者在手术完成后TIMI血流分级水平,在术后2周时测定两组LVEF%、BNP以及血浆CK-MB。结果两组患者在术后即刻血管造影提示观察组TIMI血流分级的3级血流比例显著优于对照组(P<0.05);术后2周时LVEF%观察组显著优于对照组,BNP、CK-MB峰值方面观察组显著低于对照组(P<0.05)。出院后随访1年中,观察组的心血管不良事件发生率显著少于对照组(P<0.05)。结论对于急性心肌梗死患者来说,进行PCI治疗同时联合血栓抽吸术、替罗非班可在早期更有效的改善患者心功能,利于患者恢复,降低心血管不良事件发生率,值得临床推广应用。
Objective To analyze the clinical effect of thrombolysis combined with tirofiban interventional therapy in patients with acute myocardial infarction. Methods A total of 84 acute myocardial infarction patients from June 2012 to June 2014 were enrolled in this study. They were randomly divided into observation and control groups, 42 patients in each group. Patients in both groups underwent percutaneous coronary intervention (PCI). Patients in the observation group were treated with thrombectomy combined with tirofiban, while those in the control group were treated with tirofiban alone. The levels of TIMI blood flow were compared between the two groups after operation, and LVEF%, BNP and plasma CK-MB were measured at 2 weeks after operation. Results Immediate postoperative angiography showed that the ratio of grade 3 blood flow in the TIMI grading group was significantly better than that in the control group (P <0.05). The level of blood flow in the LVEF% group was significantly better than that of the control group at 2 weeks after operation , CK-MB peak in the observation group was significantly lower than the control group (P <0.05). One year after discharge, the incidence of cardiovascular adverse events in the observation group was significantly less than that in the control group (P <0.05). Conclusion For patients with acute myocardial infarction, PCI combined with thrombus aspiration, tirofiban in the early more effective in improving cardiac function, help patients recover and reduce the incidence of adverse cardiovascular events, it is worthy of clinical application .