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目的:研究借助磁共振成像(magnetic resonance imaging,MRI)可定位的Eudragit-E液体栓塞剂(MR-E)的制备方法,并对其体外和体内的性质进行研究。方法:采用化学共沉淀法制备聚乙二醇修饰的超顺磁性氧化铁(polyethylene glycol-modified superparamagnetic iron oxides,PEG-SPIO),将PEG-SPIO和Eudragit-E液体栓塞剂混合均匀制得MR-E。通过体外MRI实验考察MR-E的成像性质,并筛选PEG-SPIO的浓度。通过经微导管推注实验和体外固化实验考察MR-E的推注性能和固化性质。以家兔肾动脉为栓塞模型,考察MR-E的体内栓塞效果和磁共振成像性质。结果:MR-E中PEG-SPIO的浓度确定为2 g/L,MR-E具有良好的推注性能和固化性质,0.2 mL MR-E注入家兔肾动脉后,可以有效地栓塞肾动脉远端血管,并且通过MRI可以示踪MR-E的组织分布情况。结论:MR-E有望成为一种新型的借助MRI可定位的液体栓塞剂。
OBJECTIVE: To study the preparation of Eudragit-E liquid embolic agent (MR-E) which can be located by magnetic resonance imaging (MRI), and to study its in vitro and in vivo properties. METHODS: Polyethylene glycol-modified superparamagnetic iron oxides (PEG-SPIO) were prepared by chemical coprecipitation method and mixed with PEG-SPIO and Eudragit-E fluid embolization agent to prepare MR- E. The imaging properties of MR-E were examined by in vitro MRI experiments and the concentration of PEG-SPIO was screened. The injection properties and curing properties of MR-E were investigated by microcatheter bolus injection and in vitro curing experiments. Rabbit renal artery embolization model to investigate MR-E in vivo embolic effect and magnetic resonance imaging properties. Results: The concentration of PEG-SPIO in MR-E was determined to be 2 g / L. MR-E had good bolus and curative properties. 0.2 mL MR-E injected into rabbit renal artery could effectively embolize the renal artery End vessels, and MRI can be traced MR-E tissue distribution. Conclusion: MR-E is expected to become a new type of liquid embolization agent that can be positioned by MRI.