骨髓纤维化往往与慢性髓细胞白血病(CML)的自然史相伴随,纤维化程度的加深标志着疾病的进展。作者观察了α-干扰素(IFN-α)治疗CML后对骨髓纤维化程度的影响。 所选病例均为Ph染色体阳性的慢性期CML患者IFNα 5×10~6U/m~2·d,治疗期最少12个月,最长40个月。治疗前后分别进行骨髓活组织检查。确定骨髓纤维化分级杯准:一级,微量小硬蛋白或网状纤维占造血面积小于25％,无出血现象和人为的细胞空泡,包括脂肪沉积;二级,网状纤维占检测区域的25％～ Myelofibrosis is often associated with the natural history of chronic myeloid leukemia (CML), and the deepening of fibrosis marks the progression of the disease. The authors observed the effect of α-interferon (IFN-α) on the degree of myelofibrosis following treatment of CML. The selected cases were Ph chromosome positive chronic phase CML patients with IFNα 5×10~6U/m~2·day. The treatment period was at least 12 months and the longest was 40 months. Bone marrow biopsy was performed before and after treatment. Determine the bone marrow fibrosis classification cup standard: first-class, micro-hard protein or reticular fibers account for less than 25% hematopoietic area, no bleeding and artificial cell vacuoles, including fat deposition; secondary, reticular fibers account for the detection area 25%～