药物的溶出速率影响药物在体内的吸收和疗效。对于要求长时间在体内释药的口服控释制剂,不同部位胃肠液的 pH 特性、患者自身胃肠液 pH 的变异、个体差异等均可能对制剂在体内的控释作用发生影响,改变设计的释药速率。如果一种控释制剂的释药 Drug dissolution rate affects the absorption and efficacy of drugs in the body. For oral controlled release preparations that require prolonged in vivo drug release, the pH characteristics of gastrointestinal fluids at different sites, patient’s own variations in gastrointestinal fluid pH, individual differences, etc., may all influence the controlled release of the formulation in vivo and alter the design Release rate. If a controlled release formulation is released