盐酸普魯卡因的含量测定方法最常用的是亚硝酸鈉法,但由于該法用碘化鉀淀粉做外指示剂,具有操作比較复杂、終点难以掌握、指示液不能貯存等缺点。文献报道用中性紅做为內指示剂測定盐酸普魯卡因和苯佐卡因制剂的含量,在滴定終点变色明显。笔者以外指示剂法对照,用中性紅做內指示剂对盐酸普魯卡因进行了含量测定,获得滿意結果。 The most commonly used method for the determination of procaine hydrochloride is sodium nitrite method, but because of the method of potassium iodide starch as an external indicator, with more complicated operation, difficult to grasp the endpoint, the indicator solution can not be stored and other shortcomings. Reported in the literature using neutral red as an internal indicator determination of procaine hydrochloride and benzocaine preparations, the end of the titration discoloration significantly. I outside the indicator method control, with neutral red as an indicator of procaine hydrochloride was determined, and satisfactory results were obtained.