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目的:探讨用机械碎栓、支架取栓联合动脉注射rt-PA(重组组织型纤溶酶原激活剂)治疗急性脑血管闭塞的临床效果。方法 :对2012年1月~2013年12月期间我院收治的90例急性脑血管闭塞患者的临床资料进行回顾性研究。我们将这90例患者随机分为观察组和对照组,每组各有45例患者。我们为对照组患者使用机械碎栓联合动脉注射rt-PA进行治疗,为观察组患者使用支架取栓联合动脉注射rt-PA进行治疗。治疗结束后,比较两组患者的治疗效果。结果 :在进行治疗前,两组患者的NIHSS评分相比差异不具有显著性(P>0.05)。进行治疗后,两组患者的NIHSS评分均显著低于进行治疗前的水平,差异具有显著性(P<0.05)。两组患者的NIHSS评分相比差异不具有显著性(P>0.05)。两组患者的血管再通率相比差异不具有显著性(P>0.05)。结论 :用机械碎栓联合动脉注射rt-PA和支架取栓联合动脉注射rt-PA治疗急性脑血管闭塞均具有较好的临床效果。在临床上,应根据急性脑血管闭塞患者的具体病情为其选择合适的方法进行治疗,以确保患者临床治疗的有效性及安全性。
Objective: To investigate the clinical effect of mechanical thrombectomy, thrombolysis combined with arterial injection of rt-PA (recombinant tissue plasminogen activator) in the treatment of acute cerebrovascular occlusion. Methods: The clinical data of 90 patients with acute cerebrovascular occlusion admitted to our hospital from January 2012 to December 2013 were retrospectively studied. We divided the 90 patients into observation and control groups randomly, each with 45 patients in each group. We treated patients in the control group with mechanical disruption combined with arterial rt-PA and patients in the observation group underwent stent thrombectomy with arterial injections of rt-PA. After treatment, the treatment effect of two groups of patients was compared. Results: There was no significant difference in NIHSS scores between the two groups before treatment (P> 0.05). After treatment, the NIHSS scores of both groups were significantly lower than those before treatment, the difference was significant (P <0.05). There was no significant difference in NIHSS score between the two groups (P> 0.05). There was no significant difference between the two groups in the rate of revascularization (P> 0.05). Conclusion: Mechanical crush combined with arterial injection of rt-PA and stent thrombectomy combined with arterial injection of rt-PA in the treatment of acute cerebrovascular occlusion has a good clinical effect. Clinically, should be based on the specific conditions of patients with acute cerebrovascular occlusion for its selection of appropriate methods of treatment to ensure the effectiveness of clinical treatment and safety of patients.