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汞中毒是现代化学工业生产过程中严重危害人民健康的职业病,众所周知的日本水俣病是震惊世界的悲惨事件。但是,目前对于汞中毒的发病机理及其所引起的生物化学变化,尚没有明确的结论性意见。尤其有关检测汞对人体影响的生物化学变化的客观指标,也仍未十分满意地建立起来。因此,建立对于接触汞环境工作者的健康监护以及对汞中毒早期诊断的客观指标是一件很有意义和实用价值的工作。 作者根据汞对人体代谢的可能影响,采用J.E.Horrocks的测血清磷酸己糖异构酶活性的方法略加改进,以测定接触汞制剂工人该酶活性的变化,为汞对人体生物化学影响的理论探讨提供某些线索。本实验结果发现,有关车间工人血清中磷酸己糖异构酶的活性明显高于正常人。
Mercury poisoning is an occupational disease that seriously endangers people’s health in the production of modern chemical industry. The well-known Japanese Minamata disease is a tragedy that shocks the world. However, there is currently no clear conclusive opinion on the pathogenesis of mercury poisoning and the biochemical changes caused by mercury poisoning. In particular, objective indicators for detecting biochemical changes in the effects of mercury on humans are not yet fully satisfactory. Therefore, establishing health care for workers exposed to mercury and objective indicators of the early diagnosis of mercury poisoning is a meaningful and practical exercise. Based on the possible effect of mercury on human metabolism, the method of measuring serum hexophosphate hexose isomerase activity by JE Horrocks was slightly modified to determine the change in enzyme activity of workers exposed to mercury, as a theory of the effect of mercury on human biochemistry Discussion provides some clues. The results of this experiment found that the activity of serum phosphate hexose isomerase in the workshop workers was significantly higher than that in normal people.