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目的:探讨妊娠期糖尿病(GDM)并发子痫前期(PE)的脐动脉血流和围产结局。方法:选择产妇134例,分为GDM组65例、PE组45例、GDM+PE组24例。收集三组患者年龄、分娩孕周、孕前体重指数(BMI)、脐动脉血流阻力指数(RI)、搏动指数(PI)、收缩期最大血流速度峰值/舒张末期血流速度(S/D)及围产结局。结果:GDM+PE组患者年龄显著高于另外两组,分娩孕周显著小于另外两组;GDM+PE组的PI值、S/D值、RI值均显著高于GDM组和PE组,而GDM组和PE组之间三项脐动脉血流指标比较无统计学差异。GDM+PE组新生儿出生体重显著低于GDM组和PE组,胎儿生长受限(FGR)、早产、转NICU比例、新生儿1 min Apgar评分显著高于GDM组和PE组;GDM组与PE组在新生儿出生体重、FGR、早产、转NICU比例、新生儿1 minApgar评分比较无统计学差异。结论:GDM合并PE患者脐血流指标明显升高,易发生不良围产结局,应加强孕期监护,积极防治,改善母儿结局。
Objective: To investigate umbilical artery blood flow and perinatal outcome in gestational diabetes mellitus (GDM) complicated with preeclampsia (PE). Methods: 134 maternal women were selected and divided into GDM group (65 cases), PE group (45 cases) and GDM + PE group (24 cases). The age, gestational age, BMI, RI, PI, peak systolic / diastolic blood flow (S / D), systolic blood pressure ) And perinatal outcome. Results: The age of GDM + PE group was significantly higher than the other two groups, gestational age was significantly less than the other two groups; PI, S / D and RI values in GDM + PE group were significantly higher than those in GDM and PE groups There was no significant difference in the three umbilical arterial blood flow indexes between GDM group and PE group. The neonatal birth weight of GDM + PE group was significantly lower than that of GDM group and PE group, fetal growth restriction (FGR), preterm birth and NICU conversion ratio, Apgar score of neonatal 1 min was significantly higher than that of GDM and PE There was no significant difference in newborns’ birth weight, FGR, premature birth, NICU transfusion rate and neonatal 1 minApgar score. Conclusion: The index of umbilical blood flow in patients with GDM complicated with PE is obviously increased, and it is easy to have unhealthy perinatal outcome. Pregnancy monitoring should be strengthened and prevention and treatment should be strengthened to improve the outcome of both mother and child.