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目的:观察左卡尼汀与rHuEPO治疗维持性血液透析患者贫血的疗效。方法:规律血透患者40例随机分为两组,治疗组每次血透后静脉注射左卡尼汀1.0 g,共12周。对照组注射氯化钠溶液。结果:治疗后两组患者贫血均得到改善,治疗组Hb、Hct上升幅度及速度明显高于对照组(P<0.05),rHuEPO用量减少。结论:左卡尼汀与rHuEPO联合治疗维持性血液透析患者贫血可提高rHuEPO疗效,减少其用量。
Objective: To observe the curative effect of levocarnitine and rHuEPO on anemia in maintenance hemodialysis patients. Methods: Forty patients with regular hemodialysis were randomly divided into two groups. The patients in the treatment group were given L-carnitine 1.0 g after each hemodialysis for 12 weeks. The control group was injected with sodium chloride solution. Results: After treatment, the anemia was improved in both groups. The increase rate and speed of Hb and Hct in the treatment group were significantly higher than those in the control group (P <0.05), and the amount of rHuEPO decreased. Conclusion: L-carnitine combined with rHuEPO in maintenance hemodialysis patients with anemia can improve rHuEPO efficacy and reduce its dosage.