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目的:采用脑功能磁共振技术探讨颈性眩晕患者脑功能的改变情况。方法:前瞻性研究2015年6月至2016年6月临床诊断为颈性眩晕患者22例的相关资料，并纳入同期25例健康成年人作为对照。采用眩晕可视化评分（visual analogue scale，VAS）和眩晕残障程度评定量表（dizziness handicap inventory，DHI）评估眩晕严重程度，采用6分分类法评估眩晕的发生频率。对两组受试者进行脑部MR扫描，采集两组受试者脑功能MRI数据，数据分析采用低频振荡振幅（amplitude of low-frequency fluctuations，ALFF）技术，用于评估患者脑功能局部改变情况。将颈性眩晕组和健康对照组的ALFF值进行独立样本n t检验；采用REST软件包提取异常脑区的ALFF值，运用Pearson相关性分析探讨脑功能改变与眩晕病程和眩晕严重程度之间的相关性。n 结果:与健康对照组相比，颈性眩晕患者左侧颞上回（体素数=45，n t=-3.36）、右侧颞上回（体素数=32，n t=-2.82）和左侧缘上回（体素数=57，n t=-4.85）区域的ALFF值降低，而左侧小脑（体素数=41，n t=4.26）和右侧小脑（体素数=33，n t=4.57）的ALFF值增高（AlphaSim校正，均n P<0.05）。颈性眩晕组患者左侧和右侧颞上回ALFF值与患者病程（左n R2=0.437、右n R2=0.259）、VAS评分（左n R2=0.453、右n R2=0.341）及DHI评分（左n R2=0.553、右n R2=0.594）呈负相关（均n P<0.05），左侧和右侧小脑ALFF值与患者病程（左n R2=0.555、右n R2=0.490）、VAS评分（左n R2=0.307、右n R2=0.282）和DHI评分（左n R2=0.632、右n R2=0.591）呈正相关（均n P<0.05）。n 结论:颈性眩晕患者双侧前庭皮层自发神经活动降低，双侧小脑自发神经活动增强，脑部功能改变与眩晕病程及眩晕严重程度相关。“,”Objective:To explore the brain function changes in patients with cervical vertigo using functional MRI.Methods:Twenty-two patients who were diagnosed with cervical vertigo were recruited in this study for functional MRI (fMRI) analysis, while 25 age- and sex-matched adult healthy individuals were chose forhealthy controls. The Visual Analogue Scale(VAS) and Dizziness Handicap Inventory (DHI) were used to access the severity of cervical vertigo, and the six-point categorical rating scale was used to measure the frequency of vertigo. Functional MRI was used to investigate the regions with brain functional changes between the cervical vertigo group and the control group. All the data was analyzed using low-frequency oscillation amplitude (ALFF) to explore local brain function changes. The ALFF values between the two groups were tested by two independent samples n t-tests. Finally, the ALFF values in abnormal brain regions were extracted using the REST software package and correlated with the diseaseduration of cervical vertigo and thevertigo scores (VAS and DHI) using Pearson correlation analysis. n P 0.05). The ALFF values of left and right superior temporal gyrus were negatively correlated with the disease duration of vertigo (left n R2=0.437, right n R2==0.259), the VAS score (left n R2==0.453, right n R2==0.341) and DHI score (left n R2=0.553, right n R2=0.594), respectively, and there were significant differences (all n P values < 0.05). The ALFF values of left and right cerebellum were positively correlated with the disease duration of vertigo (left n R2==0.555, right n R2=0.490) and the VAS score (left n R2=0.307, right n R2=0.282) and DHI score (left n R2=0.632, right n R2=0.591), respectively, and the differences were significant (all n P values < 0.05).n Conclusion:Patients with cervical vertigo have reduced spontaneous nerve activity in bilateral Vestibular cortex, and increased spontaneous nerve activity in the bilateral cerebellum. The brain functional changes were correlated with the disease duration and the severity of vertigo.