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目的评价动脉粥样硬化性肾动脉狭窄(ARAS)患者应用经皮腔内肾血管成形术(PTRA)治疗的疗效。方法回顾性分析2010年12月至2017年4月收治的44例动脉粥样硬化性肾动脉狭窄患者行血管腔内治疗的临床资料,随访观察患者血压及肾功能变化情况。结果本组44例患者置入54枚支架均获得成功,随访时间6~24个月,高危组血压较术前明显降低,口服降压药物较术前明显减少,差异具有统计学意义(P<0.01),而血清肌酐水平无明显变化;普通组手术前后血压、血清肌酐水平差异无统计学意义(P>0.01)。结论对于药物治疗后,血压仍维持在160/90 mm Hg以上的动脉粥样硬化性肾动脉狭窄患者,PTRA是一种安全有效的方法。
Objective To evaluate the efficacy of percutaneous transluminal renal angioplasty (PTRA) in patients with atherosclerotic renal artery stenosis (ARAS). Methods The clinical data of 44 patients with atherosclerotic renal artery stenosis treated with endovascular therapy from December 2010 to April 2017 were retrospectively analyzed. The changes of blood pressure and renal function were observed at follow-up. Results Forty-four patients in this group were successfully treated with 54 stents. The follow-up time ranged from 6 to 24 months. The blood pressure in high-risk group was significantly lower than that before operation, and the oral antihypertensive drugs significantly decreased compared with that before operation (P < 0.01), while the level of serum creatinine had no significant change. There was no significant difference in blood pressure and serum creatinine before and after operation in general group (P> 0.01). Conclusions PTRA is a safe and effective method for the treatment of patients with atherosclerotic renal artery stenosis whose blood pressure is still above 160/90 mm Hg after medical treatment.