Nathan等报道,钙拮抗剂包括2个主要亚类,二氢吡啶类和非二氢吡啶类,并且已在高血压患者中进行大量研究。早期荟萃分析提示,短效钙拮抗剂与心血管事件和其他病因所致的死亡率高有关连。最近的荟萃分析未显示长效钙拮抗剂和其他抗高血压药类在2或3期无蛋白尿的肾脏疾病伴有低度至 Nathan et al reported that calcium antagonists include two major subclasses, dihydropyridines and non-dihydropyridines, and a large number of studies have been conducted in hypertensive patients. Early meta-analyzes suggest that short-acting calcium antagonists are associated with high cardiovascular mortality and other causative deaths. Recent meta-analyzes have not shown that long-acting calcium antagonists and other antihypertensive drugs have a low to maximal renal disease in either stage 2 or stage 3 with no proteinuria