斑马鱼作为一种标准模式脊椎动物以其独特的优势被广泛应用于发育毒理学研究,目前研究工作涉及到几乎斑马鱼所有器官系统的发育过程及在毒理学中的应用。本文从心脏发育毒性、血管和血细胞发育毒性、神经发育毒性、肝脏及肾脏发育毒性、体节、肌肉和骨骼发育毒性等方面综述了斑马鱼应用研究进展。 As a standard model of zebrafish, vertebrates are widely used in developmental toxicology for their unique advantages. The current research involves the development of almost all zebrafish organ systems and their applications in toxicology. This article reviews the advances in zebrafish applications from aspects such as cardiac developmental toxicity, developmental toxicity of blood vessels and blood cells, neurodevelopmental toxicity, developmental toxicity in the liver and kidneys, body segment, muscular and skeletal developmental toxicity.