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采用长春新碱冲击疗法联合强的松治疗小儿难治性肾病综合征 60例 ,其中单纯性肾病 2 5例 ,肾炎性肾病 35例。激素耐药性 47例 ,频繁复发性 8例 ,激素依赖性 5例。肾活检 1 0例中 ,Ig A肾病 1例 ,Ig M肾病 2例 ,弥漫系膜增生性肾小球肾炎 4例 ,微小型病变 2例 ,局灶节段性肾小球硬化 1例。经 6～ 1 0次治疗后总有效率为 91 .7%。提示长春新碱冲击疗法对小儿难治性肾病仍是一种有效疗法
Vincristine shock therapy combined with prednisone in children with refractory nephrotic syndrome in 60 cases, of which 25 cases of simple nephropathy, nephritis nephropathy in 35 cases. 47 cases of hormone resistance, frequent recurrent in 8 cases, hormone-dependent in 5 cases. 10 cases of renal biopsy IgA nephropathy in 1 case, IgM nephropathy in 2 cases, diffuse mesangial proliferative glomerulonephritis in 4 cases, 2 cases of minimally invasive lesions, focal segmental glomerulosclerosis in 1 case. After 6 to 10 times the total effective rate was 91.7%. Tip vincristine impact therapy on children refractory nephropathy is still an effective treatment