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目的观察弥可葆、前列地尔和银杏达莫联合用药治疗糖尿病周围神经病变的疗效。方法将60例2型糖尿病合并周围神经病变患者随机分成两组,对照组30例,治疗组30例。两组控制血糖方法相同,对照组给予弥可葆500μg,肌肉注射,一日一次;治疗组给予弥可葆500μg,肌肉注射,一日一次;前列地尔10μg,加入生理盐水100ml中,静脉滴注,一日一次;银杏达莫注射液20ml加入生理盐水250ml中,静脉注射,一日一次。两组疗程均为14d,观察其对神经传导速度的影响。结果治疗14d后,患者主观症状和体征有较明显改善。治疗组总有效率为86.7%,对照组总有效率为56.7%。两组疗效比较,差别有统计学意义(P<0.01)。运动传导速度和感觉传导速度两组治疗后比较,差别有统计学意义(P<0.01)。结论弥可葆、前列地尔和银杏达莫治疗糖尿病周围神经病变有显著疗效,联合用药明显优于单用神经营养药物。
Objective To observe the curative effect of combination of mepivacaine, alprostadil and ginkgo biloba on diabetic peripheral neuropathy. Methods Sixty patients with type 2 diabetes mellitus and peripheral neuropathy were randomly divided into two groups: control group (30 cases) and treatment group (30 cases). The two groups were given the same method of blood sugar control. The control group was given 500 μg of intramuscular injection once a day. The treatment group was given 500 μg of intramuscular injection once a day. Alprostadil 10 μg was added to 100 ml of normal saline and the intravenous drip Note, once a day; gingko Damo injection 20ml saline 250ml, intravenous injection, once daily. The two courses of treatment were 14d, observed the impact on nerve conduction velocity. Results 14d after treatment, the subjective symptoms and signs of patients have significantly improved. The total effective rate was 86.7% in the treatment group and 56.7% in the control group. The efficacy of the two groups, the difference was statistically significant (P <0.01). Motor conduction velocity and sensory conduction velocity after treatment in both groups, the difference was statistically significant (P <0.01). Conclusion Miraculous, alprostadil and ginkgo biloba treatment of diabetic peripheral neuropathy have a significant effect, the combination was significantly better than single neurotrophic drugs.