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目的 探讨抑癌基因 PTEN蛋白在大肠癌的表达及临床意义。方法 免疫组化 S- P法检测 92例大肠癌组织中 PTEN蛋白的表达。结果 大肠癌组织和癌旁组织 PTEN蛋白阳性率分别为 6 7.39%和 6 6 .0 7% ,与正常大肠组织 PTEN表达的差异有显著性意义 (P<0 .0 1) ,与大肠癌的组织学分级正相关 ,与淋巴结转移、临床分期和生存率无明显相关。癌和癌旁组织的 PTEN蛋白表达呈现高度的同步性 (P<0 .0 1)。结论 提示 PTEN在大肠癌的发生发展中起着重要的作用 ,它的丢失可能为大肠癌的一种信号
Objective To investigate the expression of tumor suppressor gene PTEN in colorectal carcinoma and its clinical significance. Methods The expression of PTEN protein in 92 cases of colorectal carcinoma was detected by immunohistochemical S-P method. Results The positive rates of PTEN protein in colorectal cancer tissues and adjacent tissues were 6 7.39% and 66.07%, respectively, which were significantly different from those in normal colorectal tissues (P <0.01) There was no significant correlation between histological grade and lymph node metastasis, clinical stage and survival rate. The expression of PTEN protein in cancer and paracancerous tissues was highly synchronous (P <0.01). Conclusions PTEN plays an important role in the occurrence and development of colorectal cancer, and its loss may be a signal of colorectal cancer