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通过癌胚抗原单克隆抗体（ＣＥＡＭｃＡｂ）免疫家兔获得ＣＥＡＭｃＡｂ抗独特型抗体（Ａｂ＿２），Ａｂ＿２不但能竞争抑制ＣＥＡＭｃＡｂ与大肠癌细胞ＨＴ－２９的结合，而且诱导小鼠对大肠癌细胞ＨＴ－２９的迟发性过敏反应。经过Ａｂ＿２免疫小鼠血清能和ＣＥＡ反应，提示Ａｂ＿２能诱导抗ＣＥＡ抗体（Ａｂ＿３）产生，而ＡＢ＿３又可与ＣＥＡ表达细胞大肠癌细胞ＨＴ～２９反应。上述结果提示Ａｂ＿２中含有ＨＴ－２０细胞相类似的抗原决定簇，具有模拟ＣＥＡ的独特性。
The anti-idiotypic antibody (Ab_2) of CEAMcAb was obtained by immunization of rabbit with CEAMcAb. Ab_2 not only competitively inhibited the binding of CEAMcAb to HT-29, but also induced the growth of colon cancer cells HT-29 Delayed allergic reaction. Ab 2 immunized mice serum reacted with CEA, suggesting that Ab 2 could induce the production of anti-CEA antibody (Ab 3), while AB 3 could react with CEA-expressing colon cancer cells HT 29. The above results suggest that Ab_2 contains similar antigenic determinants of HT-20 cells and has the uniqueness of mimicking CEA.