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目的观察高通量透析对维持性血液透析( maintenance hemodialysis，MHD)患者血脂、钙磷代谢、炎症、营养等指标的影响。方法将30例维持性透析患者随机分为高通量透析组和低通量透析组，比较2组治疗前及6个月后患者的总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、钙（Ca）、磷（P）、超敏C-反应蛋白（hs-CRP）、血清白蛋白(ALB)水平。结果与治疗前及低通量透析组比较，高通量透析组TG、TC、LDL、hs-CRP、P水平下降， Ca、ALB、HDL升高，其差异有统计学意义(均P<0.05)。结论高通量透析可改善维持性血液透析患者血脂、钙磷代谢、炎症及营养状态。“,”Objective: To study the impact of high--flux hemodialysis on microinflammatory lipid profile and malnutrition in maintenance hemodialysis (MHD) patients. Methods: 30 patients on MHD were randomly divided into high--flux hemodialysis group and low--flux hemodialysis group. Total cholesterol, triglyceride, high density lipoprotein, low density lipoprotein, serum calcium,serum phosphorus, high sensitivity C-reactive protein ,serum albumin, were measured before treatment and after six months in two groups. Results: Total cholesterol, triglyceride, low density lipoprotein, serum phosphorus, high sensitivity C-reactive protein were reduced in high--flux hemodialysis group compared with low--flux hemodialysis group (P <0.05). serum calcium, high density lipoprotein, ,serum albumin, were increased in high--flux hemodialysis group compared with low--flux hemodialysis group ( P < 0. 05). Conclusions: high--flux hemodialysis can improve Calcium and phosphorus metabolism lipid profile and microinflammatory malnutrition status function in hemodialysis patients.