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目的 研究ＨＬＡ配型与尸体肾移植术后早期急性排斥反应的关系。方法 将２６２ 例尸体肾移植受者按ＨＬＡ 配型的误配率（ＭＭ） 进行分组， 统计各组术后１ ～２ 个月内急性排斥反应的发生次数。结果 当ＭＭ＞ ３ 时， 若接受的器官ＨＬＡ 抗原／基因为可接受性， 术后急性排斥反应的发生率为１６．４％ ； 若供体器官ＨＬＡ 抗原／ 基因具免疫原性， 则急性排斥反应的发生率为３３ ．１ ％ ， 两者比较， Ｐ＜ ０．０５ 。结论 供受者间ＨＬＡ配型越好， 供者器官所含的具免疫原性抗原／基因对术后早期急性排斥反应发生的影响越弱。
Objective To investigate the relationship between HLA typing and early acute rejection after cadaveric kidney transplantation. Methods A total of 262 cadaveric renal transplant recipients were divided into two groups according to HLA matching mismatch rate (MM). The incidences of acute rejection within 1 ~ 2 months after operation were calculated. Results When the MM> 3, if the accepted organ HLA antigen / gene is acceptable, the incidence of postoperative acute rejection is 16.4%; if the donor organ HLA antigen / gene is immunogenic, the acute rejection The incidence of the reaction was 33. 1%, the two were compared, P <0.05. Conclusions The better the HLA matching between donors and recipients, the weaker the effect of immunogenic antigen / gene contained in donor organs on early postoperative acute rejection.