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目的:观察免疫趋化因子白细胞介素8(IL-8)在口腔鳞状细胞癌(oral squamous cell carcinoma,OSCC)患者血清中的表达,探讨其与OSCC临床病理因素的相关性。方法:应用酶联免疫反应(enzyme-linked immunosorbentassay,ELISA)测定27例处于不同临床分期的OSCC患者和10例健康体检者血清中的IL-8水平。检测结果以x±s表示,应用SPSS 13.0软件包对数据进行t检验。结果:OSCC肿瘤组患者血清IL-8水平显著高于对照组(P<0.01),临床Ⅲ、Ⅳ期OSCC患者血清IL-8水平显著高于Ⅰ、Ⅱ期患者(P<0.01);有颈淋巴结转移的OSCC患者,血清IL-8水平显著高于无转移者(P<0.01)。结论:血清IL-8水平与口腔鳞状细胞癌的病理分级、临床分期及淋巴结转移等密切相关,是一种具有应用潜力的OSCC临床检测指标。
OBJECTIVE: To observe the expression of interleukin-8 (IL-8) in the sera of patients with oral squamous cell carcinoma (OSCC) and to explore its correlation with the clinicopathological factors of OSCC. Methods: Serum levels of IL-8 in 27 patients with OSCC at different clinical stages and 10 healthy subjects were determined by enzyme-linked immunosorbentassay (ELISA). Test results to x ± s that the application of SPSS 13.0 software package for t-test data. Results: Serum levels of IL-8 in patients with OSCC were significantly higher than those in controls (P <0.01). Serum levels of IL-8 in patients with stage III and IV OSCC were significantly higher than those in patients with stage I and II (P <0.01) Serum levels of IL-8 in OSCC patients with lymph node metastasis were significantly higher than those without metastasis (P <0.01). Conclusion: The level of serum IL-8 is closely related to the pathological grade, clinical stage and lymph node metastasis of oral squamous cell carcinoma, which is a potential clinical indicator of OSCC.