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为了探讨烟雾病的病因和发病机理，用静脉注射马血清、颈局部注射马血清、颈动脉部分结扎和颈局部注射去甲肾上腺素等４种方法，建立４组烟雾病实验动物模型。结果：静脉和颈局部注射马血清两组动物的颈动脉受免疫复合物损伤后，内弹力层迂曲、断裂，中膜平滑肌细胞沿断裂处向内膜伸入增生，以致管腔狭窄或闭塞，最终因长期慢性缺血，脑内小血管及毛细血管代偿性增生，形成烟雾样血管网，与人类烟雾病在影像学、病理学和免疫组织化学等方面结果相似。揭示了变态反应，尤其是颈局部发生的免疫损伤是引起原发性烟雾病的直接病因。
In order to explore the etiology and pathogenesis of moyamoya disease, four groups of moyamoya disease animal models were established by four methods: intravenous injection of horse serum, partial injection of horse serum into the neck, partial carotid artery ligation and local injection of norepinephrine into the neck. Results: After the carotid artery was injured by the immune complex in the carotid artery of the two groups, the internal elastic layer was tortuous and ruptured. The mesangial smooth muscle cells extended into the intima along the rupture, resulting in stenosis or occlusion. Eventually due to long-term chronic ischemia, compensatory proliferation of small blood vessels and capillaries in the brain, the formation of smoke-like vascular network, and human moyamoya disease in the imaging, pathology and immunohistochemistry similar results. Revealed the allergic reaction, especially the local occurrence of cervical immune damage is the direct cause of the disease caused by moyamoya disease.