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高脂血症不仅可以导致大动脉形态和功能改变,还可以诱导微循环系统发生表型改变。这种变化主要表现为小动脉血管扩张受损、毛细血管灌流不足、小静脉黏附因子表达增加。内皮细胞、白细胞、血小板激活和免疫细胞源性细胞因子参与微循环系统对高脂血症的应答调节,表明高脂血症微循环系统的变化对大血管病变有显著影响。对高脂血症造成的微循环功能障碍和炎症进行早期干预,会有效降低缺血性疾病高致残率、致死率。
Hyperlipidemia can not only lead to changes in the morphology and function of the aorta, but also induce phenotypic changes in the microcirculation system. This change is mainly manifested as arteriolar vasodilatation impaired capillary insufficiency, small venous adhesion factor expression increased. Endothelial cells, leukocytes, platelet activation and immune cytokines are involved in the regulation of hyperlipidemia in the microcirculation system, indicating that the changes of hyperlipidemic microcirculation system have a significant effect on macrovascular disease. The early intervention of microcirculation dysfunction and inflammation caused by hyperlipidemia will effectively reduce the morbidity and mortality of ischemic diseases.