仅少数高血压患者的血压能够得到有效控制,部分原因是因为抗高血压药物治疗缺乏有效的预测方法。本项GENRES研究是一个前瞻性、随机、双盲、交叉、对照的遗传药理学研究,使用4种不同类型的抗高血压药(氢氯噻嗪25mg,比索洛尔5mg,氨氯地平5mg,氯沙坦50mg),入选208名中度高血压的 Only a small number of patients with hypertension can be effectively controlled blood pressure, in part because of the lack of an effective prediction of antihypertensive drug treatment. This GENRES study is a prospective, randomized, double-blind, crossover, controlled genetic pharmacological study using 4 different types of antihypertensives (hydrochlorothiazide 25 mg, bisoprolol 5 mg, amlodipine 5 mg, losartan 50 mg) were enrolled in 208 moderately hypertensive subjects