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新喋呤是一种衍生于鸟苷三磷酸(GPT)的吡嗪嘧啶化合物,参与四氢生物喋啶的合成。而四氢喋啶则是苯丙氨酸、酪氨酸和色氨酸羟化酶的辅酶。实验证明新喋呤由单核巨噬细胞在受到活化T淋巴细胞产生的IFN-γ的刺激后释放。当机体细胞免疫功能改变时如感染、自体免疫病和恶性肿瘤,病人尿中新喋呤含量增加。IL-2是一种由T-辅助细胞在受到抗原刺激后或对植物血凝素反应中产生的细胞活素,其功能通过与细胞表面JL-2受体结合而刺激T淋巴细胞增生。活化T细胞释放可溶性IL-2受体(SIL-2R)到血液中,通过与IL-2结合和与细胞表面的IL-2R竞争而降低IL-2功效,故血清中SIL-2R检测可作为了解T细胞活性的标志。自
Neopterin is a pyrazinopyrimidine compound derived from guanosine triphosphate (GPT), involved in the synthesis of tetrahydrobiopterin. While tetrahydropteridine is phenylalanine, tyrosine and tryptophan hydroxylase coenzyme. Experiments show that neopterin is released by mononuclear macrophages upon stimulation by IFN-γ produced by activated T lymphocytes. When the body’s cellular immune function changes such as infections, autoimmune diseases and malignancies, the patient’s urinary neopterin levels increased. IL-2 is a cytokine produced by T-helper cells upon antigen stimulation or in response to phytohemagglutination and functions to stimulate T lymphocyte proliferation by binding to the cell surface JL-2 receptor. Activated T cells release soluble IL-2 receptor (SIL-2R) into the blood and reduce IL-2 efficacy by binding to IL-2 and competing with IL-2R on the cell surface so SIL-2R detection in serum can be used as Understand the signs of T cell activity. from