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1921年H.Holthusen发现,如果在有氧存在的条件下照射,就能提高生物的辐射敏感性.从那以后,氧便成为广泛研究的辐射增敏剂.对于处在低氧状态的肿瘤,使用高压氧吸入治疗,往往难于达到预期的效果,这可能是由于氧不易到达肿瘤的中央部位.近年来,对于低氧细胞的增敏剂的研究开始盛行起来. 首先是发现N-乙基马来酰亚胺(NEM)对于低氧状态的E.Coli B/r有增敏作用,后来又发现了含有—NO基的化合物和其他一系列的低氧增敏剂.1963年,Adams和Derrey认为低氧细胞的增敏效率与以单个电子还原电位值所表示的药物的电子亲和性之间有相关关系.1969年,Adams和Cooke提出亲电子增敏作用的模型,他们认为,增敏
In 1921, H. Holthusen found that biological radiosensitivity can be enhanced if irradiated in the presence of oxygen, and oxygen has since become a widely studied radiosensitizer.For tumors in hypoxia, The use of hyperbaric oxygen inhalation therapy, often difficult to achieve the desired effect, which may be due to oxygen is not easy to reach the center of the tumor.In recent years, the research on sensitizers for hypoxic cells began to flourish.First, found that N-ethyl horse Enimide (NEM) sensitized E. coli B / r in hypoxia state and subsequently found compounds containing -NO groups and a series of other hypoxia sensitizers. In 1963, Adams and Derrey It is thought that there is a correlation between the sensitization efficiency of hypoxic cells and the electronic affinities of drugs represented by single electron reduction potential values. In 1969, Adams and Cooke proposed a model of electrophilic sensitization,