MYD88 L265P为体细胞突变,存在于约90%的Waldenstr?m巨球蛋白血症/淋巴浆细胞淋巴瘤(lymphoplasmacytic lymphoma,LPLs)中。在某些亚型的边缘区淋巴瘤(MZL)中也可检测到该突变类型,但仅部分鉴定出MZL的突变频率、临床及组织学特征。作者拓展了TaqMan等位基因特异性聚合酶链反应技术,并探索一种在石蜡包埋组织中能敏感地检测该突变的方法。本组样本包括19例LPL、88例脾脏边缘区淋巴瘤 MYD88 L265P is a somatic mutation present in about 90% of Waldenström macroglobulinemia / lymphoplasmacytic lymphoma (LPLs). This type of mutation is also detectable in some subtypes of marginal zone lymphoma (MZL) but only partially identifies the mutation frequency, clinical and histological features of MZL. The authors expanded the TaqMan allele-specific polymerase chain reaction technique and explored a method that is sensitive to detect this mutation in paraffin-embedded tissues. This group of samples, including 19 cases of LPL, 88 cases of splenic marginal lymphoma