胰岛素一直是糖尿病的治疗药,口服几乎无降血糖作用,均为注射用药,这是由于胰岛素为高分子而难于吸收,且易被蛋白分解酶分解。近年来虽报道许多非注射给药,但均未达到实用化。据报道,在小肠内投与胰岛素,分解作用主要来自糜蛋白酶。在大鼠小肠内同时投与胰岛素和糜蛋白酶抑制剂,则出现血搪下降作用。作者将 Insulin has been the treatment of diabetes, almost no oral hypoglycemic effect, are injected medication, which is due to insulin as a polymer and difficult to absorb, and susceptible to proteolytic enzyme decomposition. Although many non-injectable drugs have been reported in recent years, they have not been put into practical use. It has been reported that insulin is administered in the small intestine, mainly from chymotrypsin. Administration of insulin and chymotrypsin inhibitors simultaneously in the small intestine of the rats results in a decrease in blood glucose. The author will