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目的:探讨白介素-4(IL-4)和白介素-8(IL-8)在高原慢性肺心病发病机制中的作用和意义。方法:高原肺心病急性加重期患者66例、缓解期患者61例,健康对照组35例,分别测血清IL-4、IL-8、肺功能和血气。结果:肺心病急性加重期血清IL-4、IL-8、PaCO2高于缓解期,缓解期高于对照组(P均<0.01),急性加重期FEV1%、FEV1/FVC、PaO2低于缓解期,缓解期低于对照组(P均<0.01)。急性加重期和缓解期血清IL-4、IL-8与FEV1%、FEV1/FVC、PaO2呈负相关,与PaCO2呈正相关(P均<0.01)。结论:IL-4、IL-8参与了高原肺心病的气道炎症反应。检测血清IL-4、IL-8浓度变化可作为高原肺心病患者病情和疗效判断的有效指标。
Objective: To investigate the role and significance of interleukin-4 (IL-4) and interleukin-8 (IL-8) in the pathogenesis of altitude sickness in patients with chronic cor pulmonale. Methods: Sixty-six patients were randomly divided into control group (n = 66), remission stage (n = 61) and healthy control group (n = 35). Serum IL-4, IL-8, Results: Serum levels of IL-4, IL-8 and PaCO2 in patients with acute exacerbation of pulmonary heart disease were significantly higher than those in the remission stage (P <0.01), FEV1%, FEV1 / FVC and PaO2 in the acute exacerbation stage were lower than those in the remission stage , And the remission period was lower than that of the control group (all P <0.01). Serum levels of IL-4 and IL-8 in acute exacerbation and remission stages were negatively correlated with FEV1%, FEV1 / FVC and PaO2, and positively correlated with PaCO2 (all P <0.01). Conclusion: IL-4 and IL-8 are involved in the airway inflammation of plateau cor pulmonale. Detection of serum IL-4, IL-8 changes in the concentration of pulmonary heart disease can be used as a valid indicator of disease severity and efficacy.