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目的分析福建省耐药监测点纳入的280例复治肺结核患者在不同年龄组的耐药情况,为结核病临床治疗和控制工作提供参考。方法收集一定时间段内在结核病门诊登记的复治结核病患者的痰液,经涂片镜检、分离培养后,用国家推荐的比例法对培养阳性的菌株进行菌型鉴定和一线抗结核药物的敏感性测定。结果 280例复治病例的总耐药率36.78%,其中耐单药率为12.5%,多耐药率为8.57%,耐多药率为15.71%,各年龄组耐单药率(χ2=3.69,P>0.05)、多耐药率(χ2=6.52,P>0.05)、耐多药率(χ2=10.56,P>0.05)差别无统计学意义。结论福建省复治肺结核患者耐药疫情虽然在国内处于较低水平,但是青壮年耐药情况有上升趋势,要引起足够的重视。
Objective To analyze the drug resistance of 280 patients with re-treatment of pulmonary tuberculosis in different age groups in drug resistance surveillance stations in Fujian Province, and provide references for the clinical treatment and control of tuberculosis. Methods The sputum samples from retreatment tuberculosis patients who were enrolled in TB clinic during a certain period of time were collected and microscopically examined. After isolating and culturing, sputum samples of positive cultures were screened by the national ratio method and were sensitive to first-line anti-tuberculosis drugs Sex Determination. Results 280 cases of re-treatment cases of total drug resistance rate of 36.78%, of which the single drug resistance rate was 12.5%, multi-drug resistance rate was 8.57%, multi-drug resistance rate was 15.71%, monolayer resistant rate in all age groups (χ2 = 3.69 , P> 0.05). There was no significant difference between multidrug resistance rate (χ2 = 6.52, P> 0.05) and multidrug resistance rate (χ2 = 10.56, P> 0.05). Conclusions Although the drug-resistant epidemic of patients with pulmonary tuberculosis in Fu-Chi Province is at a relatively low level in China, the drug-resistant status of young adults is on the rise and should be given sufficient attention.