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目的观察消心痛胶囊长期口服对大鼠机能及形态学的影响。方法将 80只Wistar大鼠随机分成空白及消心痛胶囊低剂量、中剂量、高剂量组 ,分别以不同剂量消心痛胶囊给大鼠连续灌胃 3个月 ,观察其一般情况、体重、血细胞、各项血液生化指标及 1 4个主要组织器官形态学改变以及停药 2周后上述改变恢复情况。结果一般状况无异常 ,各项指标均无异常改变。结论消心痛胶囊长期口服安全 ,无明显毒副作用 ,提示推荐的临床使用剂量基本安全
Objective To observe the effect of Xiaoxintong Capsule on the function and morphology of rats for long-term oral administration. Methods Eighty Wistar rats were randomly divided into blank and low-dose, middle-dose and high-dose groups of Xiaoxintong capsule. The rats were given different doses of Xiaoxintong capsule for 3 months, and their general condition, body weight, blood cells were observed. Blood biochemical indicators and morphological changes of 14 major tissues and organs, as well as the above changes after 2 weeks of drug withdrawal. Results No abnormalities were observed in the general conditions, and no abnormal changes were found in any of the indicators. Conclusion Xiaoxintong capsule is safe and long-term and has no obvious toxic and side effects, suggesting that the recommended dose for clinical use is basically safe.