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过去的三百年中,抗疟药并未按其药动学性质而确定给药的剂量和方法。为此,本文汇集有关资料加以报道。奎宁奎宁静滴比静注安全。经实验发现,在对恶性疟治疗过程中,静滴4h 后血药浓度比肌注或口服高20～40%。首剂4h 静滴最适用于恶性疟疾。奎宁静滴后,其体内过程符合二室模型,呈快速分布相(t(1/2)_α=1.9min)和慢速消除相(t(1/2)_β=11.1h)。其中央室的表观分布容积(Vd)
Over the past three hundred years, antimalarial drugs have not been determined according to their pharmacokinetic properties to determine the dosage and method of administration. To this end, this article brings together relevant information to be reported. Quinine quinine intravenously than static safety. The experiment found that in the course of treatment of falciparum malaria, plasma concentration 4h after intravenous infusion of intramuscular or oral 20 ~ 40% higher. The first dose of 4h intravenous drip most suitable for falciparum malaria. After intravenous infusion of quinine, the in vivo process accorded with a two-compartment model with rapid distribution phase (t (1/2) _α = 1.9 min) and slow elimination phase (t (1/2) _β = 11.1 h). The central chamber of the apparent distribution volume (Vd)