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胰腺-十二指肠同源盒1(PDX-1)是在胰腺发育中起重要作用的转录因子。小GTP酶Ran、β2肾上腺素受体等物质可通过调节PDX-1基因的表达来影响胰岛素的合成。此外,PDX-1可诱导非胰岛细胞如骨髓间充质干细胞、脂肪源性干细胞等向胰岛素分泌细胞分化,提示PDX-1在胰岛β细胞再生,促进胰岛β细胞恢复中有着巨大潜能。
Pancreatic-duodenal homeobox 1 (PDX-1) is a transcription factor that plays an important role in the development of the pancreas. Small GTPase Ran, β2 adrenoceptor and other substances can affect the insulin synthesis by regulating the expression of PDX-1 gene. In addition, PDX-1 can induce non-islet cells such as bone marrow mesenchymal stem cells and adipose-derived stem cells to differentiate into insulin-secreting cells, suggesting that PDX-1 has great potential in pancreatic β-cell regeneration and pancreatic β-cell recovery.