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62名健康男性,自愿接受每周1次200mg庚酸睾酮(TE)肌肉注射的避孕方法研究。4人非医学原因中断试验,其余受试者先后实现无精子,自第1次注射TE到全部达到无精子的平均时间为108(58～232)天,在此后的连续12个月共592个妇女月避孕效果观察中,有1例怀孕,临床避孕率为98％(Pearl指数为2.02/100妇女年)。停药后,平均188(135～254)天全部受试者的精子密度恢复到用药前水平或高于20×10~6/ml。在用药期间,除预料的血清睾酮升高、促性腺激素(FSH、LH)受抑制、睾丸体积缩小、体重和血红蛋白轻度增加以及2例出现轻度痤疮外,其余检查,包括血脂代谢、肝肾功能、前列腺大小、血压和性功能等均无显著性改变。结果表明,由TE抑制生精作用的男性激素避孕方法具有效果好,可逆和毒副作用小的优点。
Sixty-two healthy men volunteered to receive contraceptive methods for 200 mg intramuscular testosterone (TE) once per week. Four non-medical reasons for discontinuation of the test, and the remaining subjects have achieved azoospermia, from the first injection of TE to achieve the total azoospermia average time was 108 (58 ~ 232) days, after a continuous 12 months a total of 592 In the observation of women’s contraceptive effectiveness, 1 case was pregnant, and the clinical contraceptive rate was 98% (Pearl Index 2.02 / 100 woman years). After discontinuation, sperm densities were restored to pretreatment levels or above 20 x 10 ~ 6 / ml for all subjects on average 188 (135 ~ 254) days. Except for the expected increase in serum testosterone, suppression of gonadotropin (FSH, LH), testicular volume reduction, mild increase in body weight and hemoglobin, and mild acne in 2 patients, the remaining tests included lipid metabolism, liver No significant changes were found in renal function, prostate size, blood pressure and sexual function. The results showed that the male hormonal contraceptive method by TE inhibition of spermatogenesis has the advantages of good effect, reversible and small side effects.