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目的:探讨青年女性高尿酸血症与冠心病发病的关系。方法:回顾性分析468例行冠状动脉造影的青年女性患者临床资料,根据冠状动脉造影结果分为2组,有冠心病者159例为冠心病组,无冠心病者309例为对照组。观察2组吸烟史、高血压病、2型糖尿病、高脂血症、冠心病家族史及高尿酸血症与冠心病发病的关系。结果:冠心病组高尿酸血症比例(11.32%)明显高于对照组(4.21%),差异有统计学意义(P<0.05)。冠心病组合并高血压病、2型糖尿病、高胆固醇血症比例明显高于对照组(P<0.05)。Logistic回归分析显示,冠心病的独立相关危险因素依次为2型糖尿病、高尿酸血症、高血压病。结论:高尿酸血症是青年女性冠心病的独立相关危险因素。
Objective: To investigate the relationship between young female hyperuricemia and coronary heart disease. Methods: The clinical data of 468 young female patients undergoing coronary angiography were retrospectively analyzed. According to the results of coronary angiography, they were divided into two groups. 159 patients with coronary heart disease were coronary heart disease group and 309 patients without coronary heart disease were control group. The relationship between smoking history, hypertension, type 2 diabetes mellitus, hyperlipidemia, family history of coronary heart disease, hyperuricemia and coronary heart disease was observed. Results: The percentage of hyperuricemia in CHD group was significantly higher than that in control group (11.32% vs 4.21%, P <0.05). Coronary heart disease combined with hypertension, type 2 diabetes, hypercholesterolemia was significantly higher than the control group (P <0.05). Logistic regression analysis showed that the independent risk factors of coronary heart disease were type 2 diabetes, hyperuricemia and hypertension. Conclusion: Hyperuricemia is an independent risk factor for coronary heart disease in young women.