目的：观察局部晚期肝门部胆管癌姑息性引流术后１９２Ｉｒ腔内放疗的疗效。方法：先行手术探查尽可能刮除肿瘤并放置Ｕ型管引流，术后再经导管腔内放疗。参考点距离放射源中心轴１０ｍｍ，总量２４～３０Ｇｙ／３次。３例配合肝动脉区域性灌注化疗，１例配合外照射ＤＴ４５Ｇｙ／４．５周。结果：生存期６～２６个月，中位生存期１１．５月。１５例死亡，１例目前存活８个月。全组１年生存率３７．５％，２年生存率６．０％，结论：局部晚期肝门部胆管癌姑息性引流术后腔内放疗可提高生存期及生活质量 Objective: To observe the therapeutic effect of 192Ir intra-cavity radiotherapy after palliative drainage of locally advanced hilar cholangiocarcinoma. Methods: First surgical exploration as possible curettage and placement of U-tube drainage, and then catheterized intra-radiotherapy. The reference point is 10 mm from the central axis of the radioactive source and the total amount is 24-30 Gy / 3 times. Three patients received regional chemotherapy with hepatic artery, and one patient received DT45Gy / 4.5 weeks. Results: The survival of 6 to 26 months, the median survival of 11.5 months. Fifteen died and one survived for eight months. The overall 1-year survival rate 37.5%, 2-year survival rate of 6.0%, Conclusion: Local advanced hilar cholangiocarcinoma palliative drainage after endovascular radiotherapy can improve survival and quality of life