目的 :研究阿霉素在Co/GC离子注入修饰超微电极上的电化学行为。方法 :阿霉素在 0 1mol·L-1HAc NaAc ( pH 4 73 )缓冲溶液中 ,用Co/GC离子注入修饰超微电极进行伏安测定。 结果 :得到一良好的还原峰 ,峰电位Ep =- 0 5 2 0V(vs .SCE)。峰电流与阿霉素的浓度在 1 0× 10 -7～ 2 0× 10 -6 mol·L-1和 2 0× 10 -6 ～ 1 0× 10 -5mol·L-1范围内成线性关系。检出限为 3 0× 10 -8mol·L-1。用于病人尿样测定 ,得到满意的结果 ,回收率为 96 3 %～ 10 6 1%。用线性扫描和循环伏安法研究了体系的电化学行为及电极反应机理。结论 :实验表明 ,体系属两电子还原的准可逆吸附过程 Objective: To study the electrochemical behavior of doxorubicin on Co / GC ion-implanted modified electrode. Methods: Amounts of doxorubicin in 0 1 mol·L-1HAc NaAc (pH 4 73) buffer solution were measured by voltammetry using Co / GC ion implantation modified electrode. Results: A good reduction peak was obtained with a peak potential Ep = -0.520 V (vs. SCE). The peak current was linear with doxorubicin concentration in the range of 1 × 10 -7 ~ 2 × 10 -6 mol·L -1 and 2 × 10 -6 ~ 10 × 10 -5 mol·L -1 . The detection limit was 30 × 10 -8 mol·L-1. For the determination of the urine of patients, satisfactory results were obtained, the recovery rate of 96 3% ~ 10 6 1%. The electrochemical behavior and electrode reaction mechanism of the system were investigated by linear sweep and cyclic voltammetry. Conclusion: The experiment shows that the system is a quasi-reversible adsorption process of two-electron reduction