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用ＣＣｌ＿４诱导大鼠肝纤维化模型，以肝功能、体内透明质酸（ＨＡ）含量变化、肝脏病理损害及胶原增生程度为指标，研究汉防已甲素（Ｔｅｔ）对实验性肝纤维化的防治作用。结果显示各期治疗组大鼠体内ＨＡ含量、血清谷丙氨酸转氨酶＊均低于模型组。３周治疗组大鼠肝脏细胞变性、坏死及炎细胞浸润程度均显著低于模型组。１２周模型组成纤维细胞增生达２．８级，肝脏用ＨＥ及ＶＧ染色显示假小叶已形成，治疗组有成纤维细胞及胶原增生，但肝小叶形态完整。表明Ｔｅｔ能显著改善肝功能，减轻肝脏病理损害程度，抑制肝脏细胞外间质合成。
The model of hepatic fibrosis induced by CCl_4 was established. The changes of hepatic function, the content of hyaluronic acid (HA), pathological damage of liver and the degree of collagen hyperplasia were used as indexes to study the effect of tetrandrine on experimental hepatic fibrosis Prevention and treatment. The results showed that the content of HA and serum ALT in rats in each treatment group were lower than those in model group. 3 weeks treatment group rats liver degeneration, necrosis and inflammatory cell infiltration were significantly lower than the model group. Twelve-week model group fibroblast hyperplasia reached 2.8, the liver staining with HE and VG pseudobulb had been formed, the treatment group fibroblasts and collagen hyperplasia, but the integrity of the hepatic lobule. That Tet can significantly improve liver function, reduce the degree of liver pathological damage, inhibition of liver extracellular matrix synthesis.