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提出了非相关成分参比一倍率导数光谱法用于测定混合组分体系的基本原理和实验方法。本法可用于待测成分和非相关成分导数光谱严重重叠且待测成分含量较低时的不经分离直接测定。试用本法消除了甲氧苄啶(TMP)和磺胺甲嚼唑(SMZ)及附加剂之间的相互干扰,从而测定了部分制剂中的TMP:用“零交法”测定了SMZ,平均回收率分别为:102.5±1.63%(CV)和100.3±0.99%(CV)。
The basic principles and experimental methods for the determination of mixed component systems were proposed using non-relevant components reference one-time derivative spectroscopy. This method can be used for the direct determination of the uncoupled spectra when the derivative spectra of the test and unrelated components are heavily overlapped and the content of the test component is low. Trial This method eliminates the interference between trimethoprim (TMP) and sulfamethoxazole (SMZ) and additives to determine the TMP in some formulations: SMZ was measured using the “zero-crossing method” and the average recovery The rates were: 102.5 ± 1.63% (CV) and 100.3 ± 0.99% (CV).