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目的:分析近年来抗胆碱类药眼用制剂的不良反应(ADR),为临床安全用药提供资料。方法:检索1995～2009年国内医药学期刊,获得相关ADR的文献报道,按患者性别、年龄,ADR等进行统计分析。结果:共获得相关文献35篇,ADR59例。其中阿托品滴眼液引起的31例(52.5%),阿托品眼膏引起的3例(5.1%),复方托吡卡胺滴眼液引起的25例(42.4%)。结论:阿托品滴眼液的所致ADR比率例数最大,复方托吡卡胺滴眼液次之。ADR的发生与使用方法、药物剂型,个体差异等均有关系。建议用药时密切关注。
Objective: To analyze the adverse reactions (ADRs) of anticholinergic ophthalmic preparations in recent years and provide information for clinical safe medication. Methods: We searched the domestic medical journals from 1995 to 2009 and obtained the related reports of ADR. The data were analyzed according to patient’s sex, age and ADR. Results: A total of 35 articles were obtained and 59 cases of ADR were obtained. Among them, 31 cases (52.5%) caused by atropine eye drops, 3 cases (5.1%) caused by atropine eye ointment and 25 cases (42.4%) caused by compound topiramate eye drops. Conclusion: Atropine eye drops caused by the largest number of cases of ADR rate, followed by compound tropicamide eye drops. ADR occurs with the use of methods, pharmaceutical dosage forms, individual differences are related. It is recommended to pay close attention to medication.