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作者研究了50名正常妊娠和72名先兆子痫孕妇的血清尿酸浓度发现,后者的浓度较前者的要高得多。此外还发现,胎儿生长缓慢、出现产期迫窘者先兆子痫的机会也大大增加。妊娠末期胎儿死亡也会造成母体血清尿酸浓度升高,胎儿体重,母体血红蛋白和红细胞数量也与尿酸浓度有一定关系。正常妊娠初期,孕妇血清尿酸浓度大幅度下降,后又逐渐上升,至妊娠后期上升至孕前水平。其原因是妊娠初期孕妇尿酸清除率成倍增加。细胞外液尤其是循环血量的增加,有效地阻止了尿酸在肾小管的重吸收。子痫患者肾脏有一定的形态学变化,除使蛋白质的滤出发生改变外,也使肾血流和尿酸的重吸收发生了改变。母亲肾脏病变可能是尿酸浓度增高特
The authors investigated serum uric acid concentrations in 50 normal and 72 preeclamptic pregnancies at much higher concentrations than the former. In addition, it was also found that fetal growth is slow, the chances of preeclampsia are also greatly increased. Fetal death in late pregnancy can also cause maternal serum uric acid concentrations, fetal weight, maternal hemoglobin and erythrocyte numbers also have a certain relationship with uric acid concentration. Early normal pregnancy, serum uric acid levels of pregnant women dropped significantly, and then gradually increased until the late pregnancy rose to pre-pregnancy levels. The reason is that during early pregnancy uric acid clearance doubled. Extracellular fluid, especially the increase in circulating blood volume, effectively prevent uric acid in renal tubular reabsorption. The kidneys of eclampsia have some morphological changes, in addition to the protein filter out changes, but also to renal blood flow and uric acid reabsorption has changed. Maternal kidney disease may be increased uric acid concentration