论文部分内容阅读
目的:分析迟发狼疮性肾炎(LN)患者的临床与病理特点。方法:21例发病年龄≥50岁,有肾脏损害的临床表现并行肾活检病理检查的LN患者作为迟发组,随机选取同期发病年龄<50岁的132例LN患者作为对照组。肾活检病理按照2003年ISN/RPS分型方案。回顾性分析迟发LN患者的临床与病理特点。结果:迟发组平均年龄(54.8±5.4)岁,对照组平均(28.7±7.5)岁;迟发组男性比例相对增多,女性与男性比例为6∶1,对照组为7.3∶1;高血压、肾功能损害的比例高于对照组,肾脏病理类型分布与对照组无差异;面部红斑、脱发的发生率低于对照组,白细胞减少的比例升高;血清A-dsDNA、抗心磷脂抗体阳性率、低C3血症的发生率较对照组高。结论:迟发LN临床表现与对照组存在一定差异。
Objective: To analyze the clinical and pathological features of patients with delayed lupus nephritis (LN). Methods: Totally 132 LN patients with onset age> 50 years and clinical manifestations of renal damage who underwent pathological examination of renal biopsy as the late-onset group were randomly selected as the control group. Kidney biopsy pathology in accordance with the 2003 ISN / RPS classification scheme. The clinical and pathological features of late LN patients were retrospectively analyzed. Results: The average age of late onset group (54.8 ± 5.4) years old and control group (28.7 ± 7.5) years old; the proportion of male in late group increased relatively, the ratio of female to male was 6:1, the control group was 7.3:1; , The proportion of renal damage was higher than that of the control group, and there was no difference in the distribution of pathological types between the kidney and the control group. The incidence of facial erythema and alopecia was lower than that of the control group, and the percentage of leukopenia was higher. Serum A-dsDNA and anticardiolipin antibodies Rates, low incidence of C3 hyperlipidemia than the control group. Conclusion: The clinical manifestations of late LN and control group there is a certain difference.