论文部分内容阅读
观察了重组人睫状神经营养因子(rhCNTF)对5个肿瘤细胞系(大鼠胶质瘤C6系,人多形性胶质母细胞瘤SHG-44系,小鼠黑色素瘤B16系,人胃粘液腺癌MGC-803系和人肝细胞癌SMMC-7721系)体外增殖的影响。发现rhCNTF(20ng/ml~2000ng/ml)可抑制C6和SHG-44细胞增殖,对B16细胞有刺激增殖作用,但对MGC-803和SMMC-7721细胞的增殖无明显影响。结果表明,rhCNTF对肿瘤细胞生长的影响是非常复杂的,可能与其参与瘤细胞的生长调节有关
Observed recombinant human ciliary neurotrophic factor (rhCNTF) against five tumor cell lines (rat glioma C6 line, human glioblastoma multibody line SHG-44 line, mouse melanoma line B16 line, human stomach Effects of Mucogen Adenocarcinoma MGC-803 and Human Hepatocellular Carcinoma SMMC-7721) in vitro Proliferation. RhCNTF (20ng/ml-2000ng/ml) inhibited the proliferation of C6 and SHG-44 cells and stimulated the proliferation of B16 cells, but had no significant effect on the proliferation of MGC-803 and SMMC-7721 cells. The results show that the effect of rhCNTF on the growth of tumor cells is very complex and may be related to its involvement in the growth regulation of tumor cells.