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目的：观察胺碘酮联合小剂量美托洛尔治疗急性心肌梗死（AMI）并室性心律失常的临床疗效。方法选取入院治疗的 AMI 并室性心律失常患者76例为研究对象，采用抽签法将患者分为两组，对照组采用胺碘酮治疗，观察组在对照组的基础上辅以小剂量美托洛尔，观察两组患者的临床疗效，记录治疗后左心室舒张末容量（LVEDV）、心率（HR）、左室射血分数（LVEF）。结果观察组治疗有效率为84.21%，高于对照组（63.16%）；观察组室性心律失常治疗有效率为92.11%，高于对照组（63.86%），差异有统计学意义（P ﹤0.05）。观察组治疗后 HR、LVEDV 分别为（67.26±21.08）次/ min、（128.67±22.58）ml，均低于对照组；LVEF 为（42.36±5.54）ml，高于对照组，差异有统计学意义（P ﹤0.05）。结论在胺碘酮治疗 AMI 并室性心律失常的基础上辅以小剂量美托洛尔能够提高临床疗效，改善患者的心功能。“,”Objective To observe the clinical efficacy of amiodarone combined with small dose of metoprolol on acute myo-cardial infarction(AMI)and ventricular arrhythmia. Methods Seventy-six patients with AMI and ventricular arrhythmias were selected as research objects and divided into two groups,the patients in control group were given amiodarone treatment,and the patients in the observation group were given small dose of metoprolol in addition. The clinical effects of two groups of patients were observed and HR,LVEF,LVEDV value after treatment was recorded. Results The effective rate of treatment group (84. 21% )was higher than that of the control group(63. 16% ). The effective rate of treatment group for ventricular arrhythmia was 92. 11% and was 63. 86% in control group,there was significant difference(P ﹤ 0. 05). The observation group after treat-ment,HR,LVEDV were(67. 26 ± 21. 08)beat/ min and(128. 67 ± 22. 58)ml,which was lower than that of control group, LVEF[(42. 36 ± 5. 54 ) ml ] was higher than that of control group,there were significant differences( P ﹤ 0. 05 ). Conclusion On the basis of amiodarone in the treatment of AMI and ventricular arrhythmia,small dose of metoprolol can im-prove the clinical efficacy and improve heart function of patients.