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热性惊厥 (FC)是否导致海马硬化和成年颞叶癫疒间(TLE) ,其预后是否良好尚无定论。尽管临床回顾性研究表明 30 %～ 5 0 %的TLE患者在儿童期有长程FC史 ,但前瞻性研究没有发现FC与TLE有直接关系。近年来应用磁共振成像和膜片箝等先进技术所取得的一系列新发现更加倾向于表明FC的确能对发育期大脑造成急性和长期的损伤 ,并降低惊厥阈值 ,使脑功能处于惊厥的易感状态。相信随着对边缘系统易感神经元早期轻微损伤的探讨和控制神经元功能的某些神经活性物质基因表达的深入研究 ,不仅会对长程FC致发育期大鼠成年后出现惊厥易感状态的分子和细胞机制提供新的有意义的线索 ,而且可能会使我们对FC的临床意义及预后有更进一步的认识。
Whether or not febrile seizures (FC) lead to hippocampal sclerosis and adult temporal lobe epilepsy (TLE), its prognosis is not yet conclusive. Although clinical retrospective studies have shown that 30% to 50% of TLE patients have long-term FC history in childhood, no direct correlation between FC and TLE has been found in prospective studies. In recent years, a series of new findings obtained by using advanced technologies such as magnetic resonance imaging and patch-clamp have tended to indicate that FC does indeed cause acute and long-term damage to the developing brain and reduce the threshold of convulsion so that the brain function is easy to convulsive Feeling state It is believed that in-depth study of the early minor damage of the susceptible neurons in the limbic system and the gene expression of some neuroactive substances that control the function of neurons will not only affect the development of convulsions in adulthood Molecular and cellular mechanisms provide new meaningful clues, and may give us a better understanding of the clinical significance and prognosis of FC.