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目的:观察益气养血汤加减对乳腺癌术后化疗减毒增效的作用。方法:将46例乳腺癌患者随机分为对照组和观察组各23例,两组患者均于术后14天开始接受常规化疗,观察组患者在化疗的同时服用自拟益气养血汤加减,比较两组患者毒副反应和治疗前后生活质量变化情况。结果:观察组患者治疗后生活质量(KPS评分升高)明显改善、毒副反应减轻(骨髓抑制率、肝肾功能异常率及胃肠道反应发生率均明显降低),且改善情况明显优于对照组,差异具有统计学意义(P<0.05)。结论:益气养血汤加减联合常规乳腺癌化疗可提高患者生活质量、增强机体免疫力,具有减毒增效的作用,值得临床推广运用。
Objective: To observe the effect of Yiqi Yangxue Decoction on attenuated and synergistic effect of postoperative chemotherapy of breast cancer. Methods: Forty-six patients with breast cancer were randomly divided into control group and observation group, with 23 cases in each group. Both groups received routine chemotherapy at 14 days after operation. Patients in observation group received chemotherapy plus self-made qiqi yixue decoction , Compared the two groups of patients with side effects and quality of life before and after treatment changes. Results: After treatment, the quality of life (KPS score increased) in the observation group was significantly improved and the toxicity was reduced (the rate of myelosuppression, liver and kidney dysfunction and the incidence of gastrointestinal reactions were significantly decreased), and the improvement was obviously better than Control group, the difference was statistically significant (P <0.05). Conclusion: Yiqi Yangxue Decoction combined with conventional breast cancer chemotherapy can improve the quality of life of patients, enhance the body immunity, with attenuated and synergistic effect, worthy of clinical promotion and application.