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目的 探讨影响Ph阳性慢性粒细胞白血病 (CGL)患者生存期的因素。方法 对 2 0 9例CGL患者的临床体征、血常规和骨髓象进行单因素预后分析 ,然后对有意义的单因素用COX回归模型进行多因素综合分析。结果 2 0 9例患者中位生存时间 5 7个月 (3～ 179个月 ) ,5年生存率 48%。经COX回归多因素综合分析 ,外周血原始粒细胞、早幼粒细胞、出现有核红细胞、骨髓原始粒细胞 (≥0 0 4)为影响生存期的 4个主要因素。依评分指数公式分为低危、中危和高危组 ,中位生存时间分别为76 .0 ,5 6 .0和 31.5个月 (P <0 .0 1) ,5年生存率分别为 70 .42 %、46 .30 %和 18.18% (P <0 .0 1)。结论 提出适合我国CGL患者的预后评分指数公式。目的 探讨影响Ph阳性慢性粒细胞白血病 (CGL)患者生存期的因素。方法 对 2 0 9例CGL患者的临床体征、血常规和骨髓象进行单因素预后分析 ,然后对有意义的单因素用COX回归模型进行多因素综合分析。结果 2 0 9例患者中位生存时间 5 7个月 (3～ 179个月 ) ,5年生存率 48%。经COX回归多因素综合分析 ,外周血原始粒细胞、早幼粒细胞、出现有核红细胞、骨髓原始粒细胞 (≥0 0 4)为影响生存期的 4个主要因素。依评分指数公式分为低危、中危和高危组 ,中位生存时间分别为76 .0 ,5 6 .0和 31.
Objective To explore the factors affecting the survival of patients with Ph-positive chronic myelogenous leukemia (CGL). Methods A single factor prognostic analysis was performed on clinical signs, blood routine and bone marrow imaging of 209 patients with CGL. Then a multifactorial comprehensive analysis was performed using a significant single factor COX regression model. Results The median survival time of 209 patients was 57 months (range 3 to 179 months), and the 5-year survival rate was 48%. After comprehensive analysis of COX regression, peripheral blood blasts, promyelocytes, nucleated erythrocytes and myeloid blasts (≥0 4) were the four major factors affecting survival. According to the scoring index formula, the scores were divided into low-risk, moderate-risk, and high-risk groups. The median survival time was 76.0, 56.0, and 31.5 months (P < 0.01). The 5-year survival rate was 70. 42%, 46.30 % and 18.18% (P < 0.01). Conclusion The formula of prognostic score index suitable for CGL patients in China was proposed. Objective To explore the factors affecting the survival of patients with Ph-positive chronic myelogenous leukemia (CGL). Methods A single factor prognostic analysis was performed on clinical signs, blood routine and bone marrow imaging of 209 patients with CGL. Then a multifactorial comprehensive analysis was performed using a significant single factor COX regression model. Results The median survival time of 209 patients was 57 months (range 3 to 179 months), and the 5-year survival rate was 48%. After comprehensive analysis of COX regression, peripheral blood blasts, promyelocytes, nucleated erythrocytes and myeloid blasts (≥0 4) were the four major factors affecting survival. According to the scoring index formula, they were divided into low-risk, moderate-risk, and high-risk groups with a median survival time of 76.0, 56.0, and 31.